How does something living emerge from something that isn’t?

In this episode, Lee Cronin pushes the question back even further: before cells, before DNA, before biology as we usually think of it, what kind of process could make matter start organizing itself into something alive?

He and Michael Shermer get into assembly theory, RNA, autocatalysis, and the deeper puzzle of whether causation and selection may already be at work long before the first organism appears. The conversation also branches into consciousness, free will, and the possibility that life may be widespread in the universe, even if it looks nothing like life on Earth.

Lee Cronin is Regius Professor of Chemistry at the University of Glasgow, Scotland, where he leads one of the world’s largest multidisciplinary chemistry research groups. He has raised more than $35 million in grant funding, with current research income of $15 million, and has authored more than 350 peer-reviewed papers, including recent work published in Nature, Science, and PNAS. He and his team are trying to make artificial life forms, find alien life, explore the digitization of chemistry, understand how information can be encoded into chemicals and construct chemical computers.

On Easter Sunday, Michael asks whether the resurrection should be understood as history, myth, or something deeper.

Fewer people are having sex, fewer are forming lasting relationships, and many feel more isolated than ever. Why?

Michael Shermer sits down with neuroscientist and author Debra Soh to discuss her new book Sextinction: The Decline of Sex and the Future of Intimacy. They talk about the so-called sex recession, why modern dating feels so broken, and how social media, pornography, AI companions, and changing expectations between men and women are reshaping intimacy.

The discussion also touches on Gen Z mental health, dating apps, the manosphere, marriage, and the broader social consequences of a culture that increasingly substitutes screens for real human connection.

Debra Soh is a neuroscientist who specializes in human sexuality and biological explanations for behavior. She received her PhD from York University in Toronto and worked as a scientific researcher for eleven years. As a journalist, Soh writes about technology, health, and the politicization of science.