What if you could actually delay the process of aging? Dr. Nir Barzilai hopes to identify interventions that could do just that. He believes a class of drugs known as gerotherapeutics could be real game changers.

Dr. Barzilai walks us through his pioneering research and explains why your biological age may actually be different from your chronological age. And we break down the buzziest trends in the longevity space.

Links to resources mentioned in this episode:

Cellergy Therapeutics

How to measure biological aging in humans

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

An Updated Prioritization of Geroscience- Guided FDA-Approved Drugs Repurposed to Target Aging

Comparative Effectiveness of Metformin Versus Sulfonylureas on Exceptional Longevity in Women With Type 2 Diabetes: Target Trial Emulation

The Super Ager Family Study

Nir Barziliai, MD, on what we can learn about longevity from SuperAgers and Centenarians

Cardiovascular advantages among the offspring of centenarians

Lower all-cause, cardiovascular, and cancer mortality in centenarians' offspring

Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring

What You Should Know About NAD+ Supplements

Abstract 4168: NMN supplementation enhances proliferation and aggressiveness in UV-induced skin cancer

Note: In this show, we use “women” as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

See omnystudio.com/listener for privacy information.

Integrative health expert & naturopathic physician Dr. Robert Kachko shares his powerful framework for better understanding our biology, our ecology and our biography. His holistic approach helps patients navigate PTSD, trauma, and chronic conditions.

His work centers on some really powerful questions: Why does a body get sick? What are our symptoms trying to tell us? And how can that information be reverse engineered into a treatment plan?

Links to resources mentioned in this episode:

American Association of Naturopathic Physicians

Somatic Experiencing

Trauma and Violence

Veterans Administration National Center for PTSD

Remission from post-traumatic stress disorder in the general population

Remission from post-traumatic stress disorder in the general population

Recovery from DSM-IV post-traumatic stress disorder in the WHO World Mental Health surveys

Assessing Primary Care Contributions to Behavioral Health: A Cross-sectional Study Using Medical Expenditure Panel Survey

Clinician's Guide to Medications for PTSD

2023 U.S. Surgeon General - Our Epidemic of Loneliness and Isolation

‘Dunbar's number’ deconstructed

Why friendship and loneliness affect our health

Note: In this show, we use “women” as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

See omnystudio.com/listener for privacy information.

We’re tackling your questions about midlife hormone support. We’ll debunk common myths, unpack the research, and break down the basics of hormone support. We’ll also discuss some of the systemic benefits that may come with taking hormones, as well as important considerations for people with a history of health conditions, like cancer or stroke. Joining Dr. Elizabeth Poynor for this discussion is Atria Health Institute’s Chief Content Officer Siobhan O’Connor.

Links to resources mentioned in this episode:

(00:25:29) - Decoding Happiness in Midlife with Dr. Laurie Santos

(00:27:27) - Decoding Brain Fog with Dr. Caroline Gurvich

(00:48:00) - Decoding Partnership in Midlife with Dr. Richard Shapiro

Vaginal estrogen use in breast cancer survivors: a systematic review and meta-analysis of recurrence and mortality risks

Oral micronized progesterone for perimenopausal night sweats and hot flushes a Phase III Canada-wide randomized placebo-controlled 4 month trial

Systematic review and meta-analysis of the effects of menopause hormone therapy on risk of Alzheimer’s disease and dementia

Menopausal Hormone Therapy and Risk of Endometrial Cancer

Allopregnanolone and Reproductive Psychiatry: An Overview

Adverse Changes in Body Composition During the Menopausal Transition and Relation to Cardiovascular Risk: A Contemporary Review

The role of lifestyle medicine in menopausal health: a review of non-pharmacologic interventions

Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise

ADHD and Sex Hormones in Females: A Systematic Review

The range and variation in serum estradiol concentration in perimenopausal and postmenopausal women treated with transdermal estradiol in a real-world setting: a cross-sectional study

The use of HRT containing transdermal estradiol in women with a personal history of venous or arterial thromboembolism: A consecutive series of 115 cases

Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline (2025)

Note: In this show, we use “women” as shorthand for people with XX chromosomes. We understand sex and gender are more complex, and acknowledge the experiences we describe reach beyond that word.

See omnystudio.com/listener for privacy information.