Difficult to Treat Depression Audiobook By Chris Aiken cover art

Difficult to Treat Depression

A Carlat Guide

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Treatment-resistant depression challenges even the most experienced clinicians. This practical book bridges the gap between research and clinical application, offering experienced psychiatrists a structured approach to patients who haven't responded to conventional treatments.

You'll find:

How to personalize treatment by subtype, including: Bipolar, mixed, psychotic, vascular, inflammatory, postpartum, seasonal, and trauma-related depression

Basic and advanced augmentation strategies: Lithium, antipsychotics, thyroid, pramipexole, celecoxib, dextromethorphan, amantadine, minocycline, and d-cycloserine

Advanced somatic treatments including ECT, TMS, SNT (SAINT) TMS, ketamine/esketamine, and emerging neuromodulation therapies

Natural therapies: Lightbox, omega-3, probiotics, methylfolate, SAMe, and vitamin E

Psychotherapeutic and lifestyle approaches for treatment-resistant populations

©2025 Carlat Publishing (P)2025 Chris Aiken Mental Health Mood Disorders Psychology Psychology & Mental Health Health
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Dr Aiken and Kelly Newsome did a great job. Feels like I’m listening to the carlat podcast. Easy to understand. Practical info.

Top research

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My clinical practice has changed after reading this book and I’m excited to rethink DTTD in clinical practice

Practice-changing and hope-giving

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You won’t regret buying this book! So full of useful clinical pearls. I have really enjoyed it

Brilliant!

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